TOP TEN MOST DANGEROUS VIRUSES
#1
MARBURG VIRUS


Introduction
The virus is one of two members of the species Marburg marburgvirus, which is included in the genus Marburgvirus, family Filoviridae, order Mononegavirales. The name Marburg virus is derived from Marburg (the city in Hesse, Germany, where the virus was first discovered) and the taxonomic suffix virus. The virus was first discovered in 1967.
Marburg virus (MARV) causes Marburg virus disease in humans and nonhuman primates. The virus is considered to be extremely dangerous. The World Health Organization (WHO) rates it as a Risk Group 4 Pathogen (requiring biosafety level 4-equivalent containment).
 In the United States, the NIH/National Institute of Allergy and Infectious Diseases ranks it as a Category A Priority Pathogen[4] and the Centers for Disease Control and Prevention lists it as a Category A Bioterrorism Agent.
 It is also listed as a biological agent for export control by the Australia Group.

Transmission
The virus can be transmitted by exposure to one species of fruit bats (The reservoir host of Marburg virus is the African fruit bat, Rousettus aegyptiacus) or it can be transmitted between people via body fluids through direct contact with the fluids (blood, vaginal and anal secretions, saliva, droplets) or indirect contact to surfaces contaminated by the fluids.


Signs and symptoms
These start after an incubation period of 2 to 21 days and may inlude;
1. fever
2. sorethroat
3.chills
4. Myalgia
5. heahache
6. chest pain
7. vomitting
8. diarrhoes
9. jaundice
10. severe weight loss
11. shock
12. multiple organ failure
13. bleeding from orifices

Diagnosis
This is very difficult due to its rarity, however an ELISA or DNA/PCR test will confirm it.

Prevention
- Avoid caves with bats and sick primates.
- Provide maximum level protective gears for caregivers of suspected or confirmed cases.
-There are some experimental vaccines.

Treatment
No known cure. Treatment is supportive.

Prognosis
Mortality rate ranges from 23 to 90% depending on how early the disease is discovered and supportive treatment is commenced. 

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